diff --git a/tests/backends/base/test_creation.py b/tests/backends/base/test_creation.py
index 9593e13462..7e760e8884 100644
--- a/tests/backends/base/test_creation.py
+++ b/tests/backends/base/test_creation.py
@@ -14,6 +14,7 @@ from ..models import (
     Object,
     ObjectReference,
     ObjectSelfReference,
+    SchoolBus,
     SchoolClass,
 )
 
@@ -250,6 +251,22 @@ class TestDeserializeDbFromString(TransactionTestCase):
         self.assertIn('"model": "backends.schoolclass"', data)
         self.assertIn('"year": 1000', data)
 
+    def test_serialize_db_to_string_base_manager_with_prefetch_related(self):
+        sclass = SchoolClass.objects.create(
+            year=2000, last_updated=datetime.datetime.now()
+        )
+        bus = SchoolBus.objects.create(number=1)
+        bus.schoolclasses.add(sclass)
+        with mock.patch("django.db.migrations.loader.MigrationLoader") as loader:
+            # serialize_db_to_string() serializes only migrated apps, so mark
+            # the backends app as migrated.
+            loader_instance = loader.return_value
+            loader_instance.migrated_apps = {"backends"}
+            data = connection.creation.serialize_db_to_string()
+        self.assertIn('"model": "backends.schoolbus"', data)
+        self.assertIn('"model": "backends.schoolclass"', data)
+        self.assertIn(f'"schoolclasses": [{sclass.pk}]', data)
+
 
 class SkipTestClass:
     def skip_function(self):
diff --git a/tests/backends/models.py b/tests/backends/models.py
index 99e9e86f44..1ed108c2b8 100644
--- a/tests/backends/models.py
+++ b/tests/backends/models.py
@@ -32,6 +32,20 @@ class SchoolClass(models.Model):
     objects = SchoolClassManager()
 
 
+class SchoolBusManager(models.Manager):
+    def get_queryset(self):
+        return super().get_queryset().prefetch_related("schoolclasses")
+
+
+class SchoolBus(models.Model):
+    number = models.IntegerField()
+    schoolclasses = models.ManyToManyField("SchoolClass")
+    objects = SchoolBusManager()
+
+    class Meta:
+        base_manager_name = "objects"
+
+
 class VeryLongModelNameZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZ(models.Model):
     primary_key_is_quite_long_zzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzz = models.AutoField(
         primary_key=True