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A representative video of the 3D visualization of blood vessels in the whole uteroplacental complex in control and DHT+INS-exposed rats. To label blood vessels within the uteroplacental complex, whole tissue together with the foetus was dissected, cleared with the iDISCO method, immunolabelled with anti-CD31 (red) and anti-α-SMA (green), and imaged by light-sheet fluorescence microscopy.

Read the Open Access article for free: Defective uterine spiral artery remodelling and placental senescence in a pregnant rat model of polycystic ovary syndrome.

AJP in the News

Small RNAs Take on the Big Task of Helping Skin Wounds Heal Better and Faster with Minimal Scaring

Small RNAs Take on the Big Task of Helping Skin Wounds Heal Better and Faster with Minimal Scaring

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On the Cover

Organoid Prepared from a Cerv21 Xenograft

Organoid Prepared from a Cerv21 Xenograft
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About

The American Journal of Pathology

Cover Image - The American Journal of Pathology, Volume 194, Issue 3
Discoveries in Basic and Translational Pathobiology
Full Text Online Access, and More, to Paid Subscribers at http://ajp.amjpathol.org/

The American Journal of Pathology, official journal of the American Society for Investigative Pathology, published by Elsevier, Inc., seeks high-quality original research reports, reviews, and commentaries related to the molecular and cellular basis of disease. The editors will consider basic, translational, and clinical investigations that directly address mechanisms of pathogenesis or provide a foundation for future mechanistic inquiries. Examples of such foundational investigations include data mining, identification of biomarkers, molecular pathology, and discovery research. Foundational studies that incorporate deep learning and artificial intelligence are also welcome. High priority is given to studies of human disease and relevant experimental models using molecular, cellular, and organismal approaches.

Companion Journal

Cover Image - The Journal of Molecular Diagnostics, Volume 26, Issue 4

The Journal of Molecular Diagnostics, the official publication of the Association for Molecular Pathology (AMP), co-owned by the American Society for Investigative Pathology (ASIP), seeks to publish high quality original papers on scientific advances in the translation and validation of molecular discoveries in medicine into the clinical diagnostic setting, and the description and application of technological advances in the field of molecular diagnostic medicine.

Call for Papers

The American Journal of Pathology calls for manuscripts that address mechanisms of SARS-CoV-2 pathogenesis or provide a foundation for future mechanistic inquiries.

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