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Dodging death
Ferroptosis, a cell death mechanism induced by lipid peroxidation, is pivotal in tumor suppression. A recent study shows that tumor repopulating cells evade ferroptosis and develop resistance to therapy via subverting a lipid metabolism enzyme.
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Chemical Biology of Microbiomes
Interspecies communication in complex microbiome environments occurs through the small molecules, peptides, and proteins produced by both the host and the microbial residents, as highlighted in this collection of recent articles from Nature Portfolio.
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Programmable synthetic biomolecular condensates for cellular control
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β-Lactone formation during product release from a nonribosomal peptide synthetase
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ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system
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Structures, mechanisms and applications of RNA-centric CRISPR–Cas13