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The latest news, publications and events from Canadian Blood Services’ Medical Affairs and Innovation research and education network.
Collected news and publications from July 2018      
 

Welcome new subscribers  

Hope you're having a safe and happy summer! Thank you for subscribing to our Research and Education Round Up. Please share your comments, concerns and questions with us at centreforinnovation@blood.ca 

KUDOS

Congratulations to Canadian Blood Services' scientist, Dr. Heyu Ni (St. Michael's Hospital, Toronto), on his successful application for a Canadian Institutes of Health Research Foundation Grant. This highly competitive, prestigious award provides long-term support for the pursuit of innovative, high-impact research programs. Dr. Ni was awarded seven-years support for his project "Thrombosis and Thrombocytopenia: Novel mechanisms and treatments". 

New resources 

ResearchUnit: Platelet protein GPIbα plays an important role in regulating platelet-mediated production of thrombopoietin by the liver

 Platelets, through GPIbα, contribute to the steady-state production of thrombopoietin by the liver. This has important implications in bleeding diseases such as Bernard Soulier Syndrome and immune-mediated thrombocytopenias. 
Read more

Research Highlight: Improvements in platelet bacterial testing to support shelf life extension of Canadian Blood Services platelet products 
Read more 

Update: Clinical Guide to Transfusion, Chapter 12
Hemolytic Disease of the Fetus and Newborn and Perinatal Immune Thrombocytopenia 
Read more

Kudos

Congratulations to our 2018 BloodTechNet Award Program awardees:

Stem Cell Transplantation Multimedia Toolkit
 Warren Fingrut, University of Toronto 

Better blood transfusion – Phase two
Clare O'Reilly, BC Children's and Women's Health Centres 

Development of internet modules for serology curriculum delivery
Matthew Yan, Canadian Blood Services 

Applying educational tools of knowledge translation to reduce the inappropriate use of plasma in Ontario: a collaboration between Canadian Blood Services and Ontario hospitals
 Ziad Solh, Western University

Read more about the BloodTechNet Award Program

Recent RED blog posts

The latest posts on R.E.D., our research, education and discovery blog. 
Another new instalment in the Meet the Researcher series introduces us to one of our adjunct scientists, Dr. Elisabeth Maurer... 
Go to: 
Meet the Researcher: Dr. Elisabeth Maurer
Part 1: Lots to celebrate as ISBT comes to Toronto 
Part 2: Lots to celebrate as ISBT comes to Toronto: Local Day
Part 3: Lots to celebrate at ISBT: Research
Part 4: Lots to celebrate as ISBT comes to Toronto: Transfusion Medicine Education
Visit blog

New Publications

 

The age of blood in pediatric intensive care units (ABC PICU): study protocol for a randomized controlled trial. Tucci M, Lacroix J, Fergusson D, Doctor A, Hébert P, Berg RA, Caro J, Josephson CD, Leteurtre S, Menon K, Schechtman K, Steiner ME, Turgeon AF, Clayton L, Bockelmann T, Spinella PC; Canadian Critical Care Trials Group; Pediatric Critical Care Blood Research Network (BloodNet); Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.  Trials. 2018 Jul 28;19(1):404. doi: 10.1186/s13063-018-2809-y.

Blood coagulation dissected. Pryzdial ELG, Lee FMH, Lin BH, Carter RLR, Tegegn TZ, Belletrutti MJ. Transfus Apher Sci. 2018 Jul 20. pii: S1473-0502(18)30281-7. doi: 10.1016/j.transci.2018.07.003. [Epub ahead of print] Review.

Barriers and Enablers to Organ Donation After Circulatory Determination of Death: A Qualitative Study Exploring the Beliefs of Frontline Intensive Care Unit Professionals and Organ Donor Coordinators. Squires JE, Graham N, Coughlin M, Chassé M, Linklater S, Greenough M, Grimshaw JM, Shemie SD, Dhanani S, Knoll GA. Transplant Direct. 2018 Jun 27;4(7):e368. doi: 10.1097/TXD.0000000000000805. eCollection 2018 Jul. PMID: 30046658 

 Effect of donor age and donor relatedness on time to allogeneic hematopoietic cell transplantation in acute leukemia. Visram A, Aziz J, Bryant A, Zhang T, Cieniak C, Hamelin L, Landry C, Morris G, Mercer D, Atkins H, Huebsch L, Al-Touri S, Fulcher J, Sabloff M, Kekre N, Bredeson C, Allan D. Biol Blood Marrow Transplant. 2018 Jul 20. pii: S1083-8791(18)30411-7. doi: 10.1016/j.bbmt.2018.07.022. [Epub ahead of print]  PMID: 30036572 

Oxidative stress, eryptosis and anemia: A pivotal mechanistic nexus in systemic diseases. Bissinger R, Bhuyan AAM, Qadri SM, Lang F. FEBS J. 2018 Jul 20. doi: 10.1111/febs.14606. [Epub ahead of print] Review.  PMID: 30028073 

The Effect of Liposome Treatment on Hemorheology and Metabolic Profile of Human Red Blood Cells During Hypothermic Storage. Da Silveira Cavalcante L, Acker JP, Holovati JL. Biopreserv Biobank. 2018 Jul 16. doi: 10.1089/bio.2018.0023. [Epub ahead of print] PMID: 30010418

Pathophysiology of immune thrombocytopenia. Li J, Sullivan JA, Ni H. Curr Opin Hematol. 2018 Jul 12. doi: 10.1097/MOH.0000000000000447. [Epub ahead of print] PMID: 30015642

Gastrointestinal microbiota contributes to the development of murine transfusion-related acute lung injury. Kapur R, Kim M, Rebetz J, Hallström B, Björkman JT, Takabe-French A, Kim N, Liu J, Shanmugabhavananthan S, Milosevic S, McVey MJ, Speck ER, Semple JW.  Blood Adv. 2018 Jul 10;2(13):1651-1663. doi:  10.1182/bloodadvances.2018018903.  PMID: 29991496  

Grading the un-grade-able : Methods used to develop National, Canadian pediatric donation after Circulatory determination of death (pDCD) Guidelines. Weiss MJ, Hornby L, Shemie SD, Appleby A, Rochwerg B. J Clin Epidemiol. 2018 Jun 29. pii: S0895-4356(17)31299-4. doi: 10.1016/j.jclinepi.2018.06.008. [Epub ahead of print]  PMID: 299667293. 

MicroRNA-218-5p Promotes Endovascular Trophoblast Differentiation and Spiral Artery Remodeling. Brkić J, Dunk C, O’Brien J, Fu T, Nadeem L, Wang Y, Rosman D, Salem M, Shynlova O, Yougbaré I, Ni H, Lye SJ, Peng C. Molecular Therapy 2018 Jul 12: doi.org/10.1016/j.ymthe.2018.07.009.

Synthesis of Highly Biocompatible and Temperature-Responsive Physical Gels for Cryopreservation and 3D Cell Culture. Nagao M, Sengupta J, Diaz-Dussan D, Adam M, Wu M, Acker J, Ben R, Ishihara K, Zeng H, Miura Y, Narain R. ACS Appl Bio Mater 2018 Jul 6: DOI: 10.1021/acsabm.8b00096  

Pediatric donation after circulatory determination of death (pDCD): A narrative review. Weiss MJ, Sherry W, Hornby L. Paediatric Respiratory Reviews. 2018, Apr 14. https://doi.org/10.1016/j.prrv.2018.03.006 

Note: Bolded names indicate Canadian Blood Services’ Medical Affairs and Innovation scientists or medical directors.

Search our publications database on blood.ca 

Upcoming events

Centre for Blood Research – Research Day 2018,
When: August 16, 2018 | Where: Vancouver

  • July 27, 2018: Deadline to register for poster presentation 
  • August 10, 2018:  Deadline for all symposium registrations 

All sessions will be webcast live online and archived for future viewing at the following link: CBR RESEARCH DAY WEBCAST LINK.  

Cord Blood Connect
When: September 14 – 16, 2018, Where: Miami Beach, Fl. 

AABB 2018 Meeting
When: October 12-16, 2018 | Where: Boston |

Canadian Transplant Summit
When: October 16-20, 2018 | Where: Ottawa |

60th American Society of Hematology (ASH) Annual Meeting and Exposition
When: December 1-4, 2018 | Where: San Diego

 
View all events



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Developed in collaboration with the Canadian Blood Services Centre for Innovation. Please provide feedback on this update to Communication via Jenny Ryan jenny.ryan@blood.ca

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